Hydrochloric Acid → HCID 67071642, compound

HRID 874228Notes

Reaction equation

HRID 874228 reaction equation
[CH3:1][O:2][C:3](=[O:30])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[C:8]2[C:25](=[C:26]([F:28])[CH:27]=1)[O:24][C:11]1([CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]1)[CH2:10][C:9]2=[O:29].Cl>O1CCOCC1.C(Cl)Cl>[CH3:1][O:2][C:3](=[O:30])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[C:8]2[C:25](=[C:26]([F:28])[CH:27]=1)[O:24][C:11]1([CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1)[CH2:10][C:9]2=[O:29]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67071502HCID 67071502, compound

Product 1

HCID 67071642HCID 67071642, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

A mixture of (E)-3-{1′-tert-butoxycarbonyl-8-fluoro-4-oxo-spiro[chromane-2,4′-piperidine]-6-yl}-acrylic acid methyl ester (2.78 g, 6.63 mmol) and 4 M HCl in dioxane (3 ml) in DCM (50 ml) was stirred at RT for 5 h. The solvent was removed, the residue was triturated in DCM and filtered to give the title compound as its hydrochloride salt (2.04 g).

Workup

  1. customThe solvent was removed
  2. customthe residue was triturated in DCM
  3. filtrationfiltered

Sources & evidence

ORD record
ord-d4c90ee1fd874e2892e706730092323f
Source dataset
uspto-grants-2015_03
Patent number
US08980877B2

Reaction notes

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