Hydrochloric Acid → HCID 67071442, compound

HRID 874236Notes

Reaction equation

HRID 874236 reaction equation
C[O:2][C:3](=[O:28])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[C:8]2[C:24](=[CH:25][CH:26]=1)[O:23][C:11]1([CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:12]1)[CH2:10][C:9]2=[O:27].Cl>CC(O)=O>[CH2:16]([N:13]1[CH2:14][CH2:15][C:11]2([CH2:10][C:9](=[O:27])[C:8]3[C:24](=[CH:25][CH:26]=[C:6](/[CH:5]=[CH:4]/[C:3]([OH:28])=[O:2])[CH:7]=3)[O:23]2)[CH2:12]1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67071573HCID 67071573, compound

Product 1

HCID 67071442HCID 67071442, compoundYield 97.1%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

(−)-(E)-3-[1′-Benzyl-4-oxo-spiro(chromane-2,3′-pyrrolidine)-6-yl]-acrylic acid methyl ester (130 mg, 0.34 mmol) was hydrolyzed using aqueous HCl (20%) solution and AcOH following the procedure described in Example 1, Step A, giving (−)-(E)-3-[1′-benzyl-4-oxo-spiro(chromane-2,3′-pyrrolidine)-6-yl]-acrylic acid (120 mg) as a white solid (hydrochloride salt).

Sources & evidence

ORD record
ord-c904271db2304f2eb66acc19779f6081
Source dataset
uspto-grants-2015_03
Patent number
US08980877B2

Reaction notes

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