Hydrochloric Acid → HCID 67071421, compound

Participants

Reaction Steps

HCl 20% aq. (5 ml) was added to a suspension of (−)-(E)-3-[1′-[(S)-2-(6-methoxynaphthalen-2-yl)propanoyl]-4-oxo-spiro(chromane-2,3′-pyrrolidine)-6-yl]-acrylic acid methyl ester (600 mg, 1.20 mmol) in glacial AcOH (5 ml). The mixture was treated following the procedure used for Example 3, Step B to give (−)-(E)-3-[4-oxo-spiro(chromane-2,3′-pyrrolidine)-6-yl]-acrylic acid methyl ester (120 mg) as a white solid (free base).

Provenance & Evidence