Hydrochloric Acid → HCID 67071421, compound

HRID 874238Notes

Reaction equation

HRID 874238 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:38])/[CH:5]=[CH:6]/[C:7]1[CH:8]=[C:9]2[C:34](=[CH:35][CH:36]=1)[O:33][C:12]1([CH2:16][CH2:15][N:14](C(=O)[C@H](C3C=CC4C(=CC=C(OC)C=4)C=3)C)[CH2:13]1)[CH2:11][C:10]2=[O:37]>CC(O)=O>[CH3:2][O:3][C:4](=[O:38])/[CH:5]=[CH:6]/[C:7]1[CH:8]=[C:9]2[C:34](=[CH:35][CH:36]=1)[O:33][C:12]1([CH2:16][CH2:15][NH:14][CH2:13]1)[CH2:11][C:10]2=[O:37]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67071675HCID 67071675, compound

Product 1

HCID 67071421HCID 67071421, compoundYield 34.8%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

HCl 20% aq. (5 ml) was added to a suspension of (−)-(E)-3-[1′-[(S)-2-(6-methoxynaphthalen-2-yl)propanoyl]-4-oxo-spiro(chromane-2,3′-pyrrolidine)-6-yl]-acrylic acid methyl ester (600 mg, 1.20 mmol) in glacial AcOH (5 ml). The mixture was treated following the procedure used for Example 3, Step B to give (−)-(E)-3-[4-oxo-spiro(chromane-2,3′-pyrrolidine)-6-yl]-acrylic acid methyl ester (120 mg) as a white solid (free base).

Workup

  1. additionThe mixture was treated

Sources & evidence

ORD record
ord-1e4fcd8f817d4b4d85afeb21a41e2367
Source dataset
uspto-grants-2015_03
Patent number
US08980877B2

Reaction notes

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