Hydrochloric Acid → HCID 67071454, compound

HRID 874258Notes

Reaction equation

HRID 874258 reaction equation
[CH3:1][O:2][C:3](=[O:29])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[C:8]2[C:25](=[CH:26][CH:27]=1)[O:24][C:11]1([CH2:16][CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12]1)[CH2:10][C:9]2=[O:28].[ClH:30]>C(Cl)Cl.O1CCOCC1>[ClH:30].[CH3:1][O:2][C:3](=[O:29])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[C:8]2[C:25](=[CH:26][CH:27]=1)[O:24][C:11]1([CH2:16][CH2:15][CH2:14][NH:13][CH2:12]1)[CH2:10][C:9]2=[O:28]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67071461HCID 67071461, compound

Product 1

HCID 67071454HCID 67071454, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

(+)-(E)-3-[1′-Tert-butoxycarbonyl-4-oxo-spiro(chromane-2,3′-piperidine)-6-yl]-acrylic acid methyl ester (710 mg, 1.77 mmol) was dissolved in DCM (50 ml). 4 M HCl in dioxane (2 ml) was added and the mixture was stirred at RT for 3 h. The precipitate was filtered, washed with DCM and dried to give (−)-(E)-3-[4-oxo-spiro(chromane-2,3′-piperidine)-6-yl]-acrylic acid methyl ester hydrochloride (516 mg)

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with DCM
  3. customdried

Sources & evidence

ORD record
ord-baea600d2fa04cea80b566c26899cee0
Source dataset
uspto-grants-2015_03
Patent number
US08980877B2

Reaction notes

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