O-(Tetrahydropyran-2-yl)hydroxylamine → HCID 87258321, compound

HRID 874266Notes

Reaction equation

HRID 874266 reaction equation
[CH2:1]([N:8]1[CH2:14][CH2:13][CH2:12][C:11]2([CH2:23][C:22](=[O:24])[C:21]3[C:16](=[CH:17][CH:18]=[C:19](/[CH:25]=[CH:26]/[C:27](O)=[O:28])[CH:20]=3)[O:15]2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:30][O:31][CH:32]1[CH2:37][CH2:36][CH2:35][CH2:34][O:33]1>>[CH2:1]([N:8]1[CH2:14][CH2:13][CH2:12][C:11]2([CH2:23][C:22](=[O:24])[C:21]3[C:16](=[CH:17][CH:18]=[C:19](/[CH:25]=[CH:26]/[C:27]([NH:30][O:31][CH:32]4[CH2:37][CH2:36][CH2:35][CH2:34][O:33]4)=[O:28])[CH:20]=3)[O:15]2)[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 5142091O-(Tetrahydropyran-2-yl)hydroxylamineHCID 67071420HCID 67071420, compound

Product 1

HCID 87258321HCID 87258321, compound

Procedure

(±)-(E)-3-[1′-Benzyl-4-oxo-spiro(chromane-2,4′-azepane)-6-yl]-acrylic acid (490 mg, 1.15 mmol) was reacted with NH2OTHP following the procedure described in Example 22, Step C, giving (E)-3-[1′-benzyl-4-oxo-spiro(chromane-2,4′-azepane)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide (270 mg).

Sources & evidence

ORD record
ord-a176bb430ead4715bd194a3135b9a8e4
Source dataset
uspto-grants-2015_03
Patent number
US08980877B2

Reaction notes

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