Hydrochloric Acid → HCID 67071726, compound

HRID 874270Notes

Reaction equation

HRID 874270 reaction equation
C[O:2][C:3](=[O:24])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[C:8]2[C:20](=[CH:21][CH:22]=1)[O:19][C:11]1([CH2:17][CH2:16][CH2:15][N:14]([CH3:18])[CH2:13][CH2:12]1)[CH2:10][C:9]2=[O:23].Cl>CC(O)=O>[CH3:18][N:14]1[CH2:15][CH2:16][CH2:17][C:11]2([CH2:10][C:9](=[O:23])[C:8]3[C:20](=[CH:21][CH:22]=[C:6](/[CH:5]=[CH:4]/[C:3]([OH:24])=[O:2])[CH:7]=3)[O:19]2)[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67071538HCID 67071538, compound

Product 1

HCID 67071726HCID 67071726, compoundYield 94.6%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

(±)-(E)-3-[1′-Methyl-4-oxo-spiro(chromane-2,4′-azepane)-6-yl]-acrylic acid methyl ester (370 mg, 1.12 mmol) was hydrolyzed with HCl and AcOH according to the procedure for preparation of Example 23, Step B, giving (±)-(E)-3-[1′-methyl-4-oxo-spiro(chromane-2,4′-azepane)-6-yl]-acrylic acid (334 mg) as a white solid (hydrochloride salt).

Sources & evidence

ORD record
ord-3957dfc27e2145f9a23f13c79dd0b389
Source dataset
uspto-grants-2015_03
Patent number
US08980877B2

Reaction notes

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