O-(Tetrahydropyran-2-yl)hydroxylamine → HCID 87258291, compound

HRID 874271Notes

Reaction equation

HRID 874271 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][C:5]2([CH2:17][C:16](=[O:18])[C:15]3[C:10](=[CH:11][CH:12]=[C:13](/[CH:19]=[CH:20]/[C:21](O)=[O:22])[CH:14]=3)[O:9]2)[CH2:4][CH2:3]1.[NH2:24][O:25][CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][O:27]1>>[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][C:5]2([CH2:17][C:16](=[O:18])[C:15]3[C:10](=[CH:11][CH:12]=[C:13](/[CH:19]=[CH:20]/[C:21]([NH:24][O:25][CH:26]4[CH2:31][CH2:30][CH2:29][CH2:28][O:27]4)=[O:22])[CH:14]=3)[O:9]2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 5142091O-(Tetrahydropyran-2-yl)hydroxylamineHCID 67071726HCID 67071726, compound

Product 1

HCID 87258291HCID 87258291, compound

Procedure

(±)-(E)-3-[1′-Methyl-4-oxo-spiro(chromane-2,4′-azepane)-6-yl]-acrylic acid (330 mg, 0.94 mmol) was treated with NH2OTHP according to the procedure described in Example 23, Step C, giving (±)-(E)-3-[1′-methyl-4-oxo-spiro(chromane-2,4′-azepane)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide as a yellow solid (220 mg).

Sources & evidence

ORD record
ord-d3d291dd6b5a44b9a6bd2f0a42ef7668
Source dataset
uspto-grants-2015_03
Patent number
US08980877B2

Reaction notes

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