Hydrochloric Acid → HCID 67071446, compound

HRID 874278Notes

Reaction equation

C[O:2][C:3](=[O:27])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[C:8]2[C:23](=[CH:24][CH:25]=1)[O:22][C:11]1([CH2:14][N:13]([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:12]1)[CH2:10][C:9]2=[O:26].Cl>C(O)(=O)C>[CH2:15]([N:13]1[CH2:14][C:11]2([CH2:10][C:9](=[O:26])[C:8]3[C:23](=[CH:24][CH:25]=[C:6](/[CH:5]=[CH:4]/[C:3]([OH:27])=[O:2])[CH:7]=3)[O:22]2)[CH2:12]1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

Conditions

Temperature: 85 °C

Procedure

(E)-3-[1′-Benzyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-acrylic acid methyl ester (540 mg, 1.48 mmol) was dissolved in acetic acid (10 ml), then 6 M HCl (10 ml) was added and the resulting suspension was heated to 85° C. for 4 h. The solvents were evaporated and the residue was dried under vacuum, giving (E)-3-[1′-benzyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-acrylic acid (490 mg, hydrochloride salt) as a light yellow solid.

Workup

customThe solvents were evaporated
customthe residue was dried under vacuum

Sources & evidence

ORD record: ord-783a9af61ee646c1aa4ab9292b9ec2c5
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08980877B2

Reaction notes

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