Hydrochloric Acid → HCID 67071567, compound

Participants

Reaction Steps

(E)-3-[1′-(2-Phenyl-ethyl)-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-acrylic acid methyl ester (350 mg, 0.93 mmol) was hydrolyzed with AcOH (6 ml) and aqueous 20% HCl solution (6 ml) following the procedure described in Example 31, Step B, giving (E)-3-[1′-(2-phenyl-ethyl)-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-acrylic acid (320 mg, hydrochloride salt) as a yellow solid.

Provenance & Evidence