Hydrochloric Acid → HCID 67071567, compound

HRID 874282Notes

Reaction equation

HRID 874282 reaction equation
C[O:2][C:3](=[O:28])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[C:8]2[C:24](=[CH:25][CH:26]=1)[O:23][C:11]1([CH2:14][N:13]([CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:12]1)[CH2:10][C:9]2=[O:27].Cl>CC(O)=O>[C:17]1([CH2:16][CH2:15][N:13]2[CH2:14][C:11]3([CH2:10][C:9](=[O:27])[C:8]4[C:24](=[CH:25][CH:26]=[C:6](/[CH:5]=[CH:4]/[C:3]([OH:28])=[O:2])[CH:7]=4)[O:23]3)[CH2:12]2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67071692HCID 67071692, compound

Product 1

HCID 67071567HCID 67071567, compoundYield 94.7%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

(E)-3-[1′-(2-Phenyl-ethyl)-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-acrylic acid methyl ester (350 mg, 0.93 mmol) was hydrolyzed with AcOH (6 ml) and aqueous 20% HCl solution (6 ml) following the procedure described in Example 31, Step B, giving (E)-3-[1′-(2-phenyl-ethyl)-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-acrylic acid (320 mg, hydrochloride salt) as a yellow solid.

Sources & evidence

ORD record
ord-3575617e7727420b85f1e9894d91f17e
Source dataset
uspto-grants-2015_03
Patent number
US08980877B2

Reaction notes

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