Hydrochloric Acid → HCID 67071672, compound

HRID 874289Notes

Reaction equation

HRID 874289 reaction equation
C[O:2][C:3](=[O:21])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[C:8]2[C:17](=[CH:18][CH:19]=1)[O:16][C:11]1([CH2:14][N:13]([CH3:15])[CH2:12]1)[CH2:10][C:9]2=[O:20].Cl>CC(O)=O>[CH3:15][N:13]1[CH2:12][C:11]2([CH2:10][C:9](=[O:20])[C:8]3[C:17](=[CH:18][CH:19]=[C:6](/[CH:5]=[CH:4]/[C:3]([OH:21])=[O:2])[CH:7]=3)[O:16]2)[CH2:14]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67071595HCID 67071595, compound

Product 1

HCID 67071672HCID 67071672, compoundYield 95.7%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

(E)-3-[1′-Methyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-acrylic acid methyl ester (410 mg, 1.53 mmol) was hydrolyzed with AcOH (10 ml) and aqueous 20% HCl (10 ml) following the procedure described in Example 31, Step B, giving (E)-3-[1′-methyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-acrylic acid (400 mg, hydrochloride salt) as a pale yellow oil.

Sources & evidence

ORD record
ord-3db9579f4611441d94d1eac0f03da15d
Source dataset
uspto-grants-2015_03
Patent number
US08980877B2

Reaction notes

Loading…