Hydrochloric Acid → HCID 51357555, compound

Participants

Reaction Steps

(E)-3-[1′-Methyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide (320 mg, 0.86 mmol) in DCM (4 ml) was treated with 1 M HCl in Et2O (4 ml) as described in Example 31, Step C, giving (E)-3-[1′-methyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-N-hydroxy-acrylamide (209 mg, hydrochloride salt) as a white solid.

Provenance & Evidence