Hydrochloric Acid → HCID 51357555, compound

HRID 874291Notes

Reaction equation

HRID 874291 reaction equation
[CH3:1][N:2]1[CH2:5][C:4]2([CH2:14][C:13](=[O:15])[C:12]3[C:7](=[CH:8][CH:9]=[C:10](/[CH:16]=[CH:17]/[C:18]([NH:20][O:21]C4CCCCO4)=[O:19])[CH:11]=3)[O:6]2)[CH2:3]1.Cl>C(Cl)Cl.CCOCC>[CH3:1][N:2]1[CH2:5][C:4]2([CH2:14][C:13](=[O:15])[C:12]3[C:7](=[CH:8][CH:9]=[C:10](/[CH:16]=[CH:17]/[C:18]([NH:20][OH:21])=[O:19])[CH:11]=3)[O:6]2)[CH2:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86671985HCID 86671985, compound

Product 1

HCID 51357555HCID 51357555, compoundYield 84.3%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

(E)-3-[1′-Methyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide (320 mg, 0.86 mmol) in DCM (4 ml) was treated with 1 M HCl in Et2O (4 ml) as described in Example 31, Step C, giving (E)-3-[1′-methyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-N-hydroxy-acrylamide (209 mg, hydrochloride salt) as a white solid.

Sources & evidence

ORD record
ord-a192937757d641c6b832a6d8686337ce
Source dataset
uspto-grants-2015_03
Patent number
US08980877B2

Reaction notes

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