Hydrochloric Acid → HCID 51357823, compound

HRID 874298Notes

Reaction equation

HRID 874298 reaction equation
[C:1]([N:4]1[CH2:7][C:6]2([CH2:16][C:15](=[O:17])[C:14]3[C:9](=[CH:10][CH:11]=[C:12](/[CH:18]=[CH:19]/[C:20]([NH:22][O:23]C4CCCCO4)=[O:21])[CH:13]=3)[O:8]2)[CH2:5]1)(=[O:3])[CH3:2].Cl>C(Cl)Cl.O1CCOCC1>[C:1]([N:4]1[CH2:7][C:6]2([CH2:16][C:15](=[O:17])[C:14]3[C:9](=[CH:10][CH:11]=[C:12](/[CH:18]=[CH:19]/[C:20]([NH:22][OH:23])=[O:21])[CH:13]=3)[O:8]2)[CH2:5]1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86671987HCID 86671987, compound

Product 1

HCID 51357823HCID 51357823, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

(E)-3-[1′-Acetyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide (35 mg, 0.088 mmol) in DCM (5 ml) was treated with 4 M HCl in dioxane (0.4 ml) as described in Example 30, Step C, giving (E)-3-[1′-acetyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-N-hydroxy-acrylamide (27 mg, hydrochloride salt) as a light brown solid.

Sources & evidence

ORD record
ord-5c78119fefd04ee9b7b0f319fbb29aeb
Source dataset
uspto-grants-2015_03
Patent number
US08980877B2

Reaction notes

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