Hydrochloric Acid → HCID 86287760, compound

HRID 874462Notes

Reaction equation

HRID 874462 reaction equation
C[O:2][C:3]1[N:4]=[CH:5][CH:6]=[C:7]2[C:11]([C:12]3[CH:17]=[C:16]([CH2:18][S:19]([CH3:22])(=[O:21])=[O:20])[CH:15]=[CH:14][C:13]=3[NH:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=3)=[CH:10][N:9]([CH3:30])[C:8]=12.Cl>CO>[CH3:30][N:9]1[C:8]2[C:3](=[O:2])[NH:4][CH:5]=[CH:6][C:7]=2[C:11]([C:12]2[CH:17]=[C:16]([CH2:18][S:19]([CH3:22])(=[O:20])=[O:21])[CH:15]=[CH:14][C:13]=2[NH:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=2)=[CH:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 90387876HCID 90387876, compound

Product 1

HCID 86287760HCID 86287760, compoundYield 99.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
75 °C

Procedure

A mixture of Example 79a (0.062 g, 0.147 mmol) in methanol (1 mL) was treated with hydrogen chloride solution (4 M in 1,4-dioxane) (1 mL, 4 mmol) and heated at 75° C. for 2.5 hours. Additional hydrogen chloride solution (4 M in 1,4-dioxane) (1 mL, 4 mmol) was added and heating was continued for another 3.5 hours. The reaction mixture was concentrated to dryness to provide 0.06 g (92%) of the title compound as the HCl salt.

Workup

  1. temperatureheating
  2. concentrationThe reaction mixture was concentrated to dryness

Sources & evidence

ORD record
ord-f055977b31044f688b0b65c57e2e71d3
Source dataset
uspto-grants-2015_03
Patent number
US08980879B2

Reaction notes

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