反应详情

4-(3-chloro-4-methoxybenzyloxy)-2-(methylmercapto)-N-(pyridin-2-ylmethyl)pyrimidine-5-carboxamide (180 mg, 0.42 mmol) was dissolved in 20 ml of dichloromethane, m-CPBA (80 mg, 0.46 mmol) was added and reacted at room temperature for 12 h, washed with water after reaction, extracted with dichloromethane, the organic layer was dried, dried by rotation to obtain yellow solid, and this product was directly used in the next reaction without purification.

1. customreacted at room temperature for 12 h
2. washwashed with water
3. customafter reaction
4. extractionextracted with dichloromethane
5. customthe organic layer was dried
6. customdried by rotation
7. customto obtain yellow solid
8. customthis product was directly used in the next reaction without purification