HRID874548

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID11195928

未命名化合物

结构：COC(=O)C(CN)(C(=O)OC)N1CCN(C(=O)OC(C)(C)C)CC1

HCID57848700

未命名化合物

PRODUCTS

生成物

结构：CC#CCOc1ccc(S(=O)(=O)NCC(C(=O)OC)(C(=O)OC)N2CCN(C(=O)OC(C)(C)C)CC2)cc1

HCID71115388

未命名化合物

收率 54.2%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

1.1 ml (8 mmol) of triethylamine and then 1.8 ml (7 mmol) of 4-but-2-ynyloxybenzenesulfonyl chloride are added to a solution of 2.5 g (7 mmol) of dimethyl 2-aminomethyl-2-(4-tert-butoxycarbonylpiperazin-1-yl)malonate in 30 ml of dichloromethane. The reaction medium is stirred at ambient temperature for 2 hours and then concentrated under vacuum. The crude product obtained is purified by chromatography on silica gel, elution being carried out with a 70/30 heptane/ethyl acetate mixture. 2.1 g (51%) of dimethyl 2-(4-tert-butoxycarbonylpiperazin-1-yl)-2-[(4-but-2-ynyloxybenzenesulfonylamino)methyl]malonate are obtained in the form of a white solid.

WORKUP

后处理

concentrationconcentrated under vacuum
customThe crude product obtained
customis purified by chromatography on silica gel, elution

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-57ffa3819b0f469f90316a039fb2fa4a
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08980897B2
来源说明: uspto-grants-2015_03

反应 SMILES

C(N(CC)CC)C.[CH2:8]([O:12][C:13]1[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=1)[C:9]#[C:10][CH3:11].[NH2:23][CH2:24][C:25]([N:34]1[CH2:39][CH2:38][N:37]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[CH2:36][CH2:35]1)([C:30]([O:32][CH3:33])=[O:31])[C:26]([O:28][CH3:29])=[O:27]>ClCCl>[C:43]([O:42][C:40]([N:37]1[CH2:38][CH2:39][N:34]([C:25]([CH2:24][NH:23][S:19]([C:16]2[CH:17]=[CH:18][C:13]([O:12][CH2:8][C:9]#[C:10][CH3:11])=[CH:14][CH:15]=2)(=[O:21])=[O:20])([C:30]([O:32][CH3:33])=[O:31])[C:26]([O:28][CH3:29])=[O:27])[CH2:35][CH2:36]1)=[O:41])([CH3:45])([CH3:46])[CH3:44]