4-(2-Methylquinolin-4-ylmethoxy)benzenesulfonyl chloride hydrochloride → Methyl (S)-2-[4-(2-methylpropene-1-sulfonyl)piperazin-1-yl]-3-(4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino)propanoate

Participants

Reaction Steps

In a manner analogous to example 3.6, using 621 mg (1.6 mmol) of methyl (S)-3-amino-2-[4-(2-methylpropane-1-sulfonyl)piperazin-1-yl]propanoate dihydrochloride and 876 mg (2.3 mmol) of 4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl chloride hydrochloride (prepared as described in example 17.2), 643 mg (64%) of methyl (S)-2-[4-(2-methylpropane-1-sulfonyl)piperazin-1-yl]-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate are obtained in the form of an oil.

Provenance & Evidence