反应详情

温度

90 °C

A mixture of crude 4-4 (9.40 g, <19.3 mmol), ammonia (7 M in methanol; 150 mL, 1050 mmol), and 1,4-dioxane (50.0 mL) was placed in a 350 mL sealed tube. The resulting mixture was stirred at 90° C. for 138 hours and cooled to ambient temperature. The reaction mixture was concentrated under reduced pressure to give 10.9 g of 4-5 as a brown oil. The crude product was used for next step without further purification.

1. customsealed tube
2. temperaturecooled to ambient temperature
3. concentrationThe reaction mixture was concentrated under reduced pressure