Ammonia → N6,N6-bis(4-methoxybenzyl)-2,7-naphthyridine-1,6-diamine

Participants

Reaction Conditions

Reaction Steps

A mixture of crude 4-4 (9.40 g, <19.3 mmol), ammonia (7 M in methanol; 150 mL, 1050 mmol), and 1,4-dioxane (50.0 mL) was placed in a 350 mL sealed tube. The resulting mixture was stirred at 90° C. for 138 hours and cooled to ambient temperature. The reaction mixture was concentrated under reduced pressure to give 10.9 g of 4-5 as a brown oil. The crude product was used for next step without further purification.

Provenance & Evidence