HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 874720Generated: October 30, 2026
Formamide → N-[(Toluene-4-sulfonyl)-(3-chloro-4,5-dimethoxyphenyl)methyl]formamide
https://huagongshe.com/reaction/874720
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | p-Toluenesulfinic acid | HCID 10818 | — |
| Reactant | Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- | HCID 18462 | — |
| Reactant | 3-Chloro-4,5-dimethoxybenzaldehyde | HCID 240052 | — |
| Product | N-[(Toluene-4-sulfonyl)-(3-chloro-4,5-dimethoxyphenyl)methyl]formamide | HCID 46938394 | — |
Reaction Steps
5-Chloroveratraldehyde (5.7 g, 23.4 mmol), para-toluenesulfinic acid (3.0 g, 19.3 mmol) and camphorsulfonic acid (110 mg, 0.47 mmol) were treated with formamide (10 mL). Upon heating to 65° C. the reaction mixture turned into a solution and after two hours the product began to precipitate. After stirring for 16 h the precipitate was filtered, washed with methanol and dried in vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08980933B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-425d241388c24a97a7cc0acd27d72100 |
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| Source note | uspto-grants-2015_03 |
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