1,4-Dioxane hydrochloride → 3-(1,3-Dioxolan-2-yl)propyl piperidine-4-carboxylate hydrochloride

HRID 874810Notes

Reaction equation

HRID 874810 reaction equation
[ClH:1].O1CCOCC1.[N:8]1(C(OC(C)(C)C)=O)[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH2:18][CH2:19][CH:20]2[O:24][CH2:23][CH2:22][O:21]2)=[O:15])[CH2:10][CH2:9]1>>[ClH:1].[NH:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH2:18][CH2:19][CH:20]2[O:21][CH2:22][CH2:23][O:24]2)=[O:15])[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 867223024-(3-(1,3-Dioxolan-2-yl)propyl) 1-tert-butyl piperidine-1,4-dicarboxylate

Product 1

HCID 867223013-(1,3-Dioxolan-2-yl)propyl piperidine-4-carboxylate hydrochloride

Procedure

HCl-dioxane (4 M, 5 mL, 20 mmol) was added to 4-(3-(1,3-dioxolan-2-yl)propyl) 1-tert-butyl piperidine-1,4-dicarboxylate (0.71 g, 2.07 mmol) and the reaction mixture was stirred at RT for 1.5 hours. The solvent was evaporated at reduced pressure. The crude material was used directly without purification.

Workup

  1. customThe solvent was evaporated at reduced pressure
  2. customThe crude material was used directly without purification

Sources & evidence

ORD record
ord-4c82da05561c40a7bd066f923e983a6d
Source dataset
uspto-grants-2015_03
Patent number
US08980913B2

Reaction notes

Loading…