HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-6-chlorobenzoic acid → 2-[2-tert-butoxy-1-(9H-purin-6-ylamino)-ethyl]-3-phenyl-3H-quinazolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-6-chlorobenzoic acid | HCID 75071 | — |
| Reactant | 6-Methylanthranilic acid | HCID 151210 | — |
| Reactant | Z-O-tert-butyl-L-serine N-hydroxysuccinimide ester | HCID 2729196 | — |
| Reactant | (2,5-Dioxopyrrolidin-1-yl) 2-(phenylmethoxycarbonylamino)butanoate | HCID 12961228 | — |
| Reactant | HCID 178456854 | HCID 178456854 | — |
| Product | 2-[2-tert-butoxy-1-(9H-purin-6-ylamino)-ethyl]-3-phenyl-3H-quinazolin-4-one | HCID 178450505 | — |
Reaction Steps
2-[2-tert-butoxy-1-(9H-purin-6-ylamino)ethyl]-3-phenyl-3H-quinazolin-4one was prepared using the general procedure described above with respect to compound 14, but 2-amino-6-chlorobenzoic acid was substituted for 2-amino-6-methylbenzoic acid in step A, 2-benzyloxycarbonylamino-3-tert-butoxy-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidin-1-yl ester in step B, and the conditions used in step C removed both the benzyl protecting group and the A-Ring chloro substituent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08980901B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-d2fc2196c5f24e6894ac4c553430f792 |
| Source note | uspto-grants-2015_03 |