2,6-Dimethylpiperazine → 6-(3,5-Dimethylpiperazin-1-yl)nicotinonitrile

HRID 874929Notes

Reaction equation

HRID 874929 reaction equation
[CH3:1][CH:2]1[CH2:7][NH:6][CH2:5][CH:4]([CH3:8])[NH:3]1.Cl[C:10]1[CH:17]=[CH:16][C:13]([C:14]#[N:15])=[CH:12][N:11]=1>>[CH3:8][CH:4]1[NH:3][CH:2]([CH3:1])[CH2:7][N:6]([C:10]2[CH:17]=[CH:16][C:13]([C:14]#[N:15])=[CH:12][N:11]=2)[CH2:5]1

Participants

3

Reactant 2

HCID 660562,6-DimethylpiperazineHCID 51520946-Chloro-3-pyridinecarbonitrile

Product 1

HCID 625880796-(3,5-Dimethylpiperazin-1-yl)nicotinonitrile

Procedure

This compound was synthesized from 2,6-dimethyl-piperazine and 6-chloronicotinonitrile as described for example 39 step 1 (90 mg, crude) and it was carried through without further purification. 1H NMR (400 MHz, CDCl3) δ 8.40 (d, J=2.0 Hz, 1H), 7.60 (dd, J=9.0 Hz, J=2.3 Hz, 1H), 6.60 (d, J=9.3 Hz, 1H), 4.27 (d, J=12.8 Hz, 2H), 2.96-2.88 (m, 2H), 2.52 (dd, J=12.4 Hz, J=10.9 Hz, 2H), 1.16 (d, J=6.3 Hz, 6H)

Workup

  1. customwas carried through without further purification

Sources & evidence

ORD record
ord-a96477363d3c4c74b98d8300172c1899
Source dataset
uspto-grants-2015_03
Patent number
US08981084B2

Reaction notes

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