2,6-Dimethylpiperazine → 6-(3,5-Dimethylpiperazin-1-yl)nicotinonitrile

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Reaction Steps

This compound was synthesized from 2,6-dimethyl-piperazine and 6-chloronicotinonitrile as described for example 39 step 1 (90 mg, crude) and it was carried through without further purification. 1H NMR (400 MHz, CDCl3) δ 8.40 (d, J=2.0 Hz, 1H), 7.60 (dd, J=9.0 Hz, J=2.3 Hz, 1H), 6.60 (d, J=9.3 Hz, 1H), 4.27 (d, J=12.8 Hz, 2H), 2.96-2.88 (m, 2H), 2.52 (dd, J=12.4 Hz, J=10.9 Hz, 2H), 1.16 (d, J=6.3 Hz, 6H)

Provenance & Evidence