Trifluoroacetate → 5-(4-Fluorophenyl)-2-(piperidin-3-yl)oxazole TFA Salt

HRID 874997Notes

Reaction equation

HRID 874997 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH:13]3[CH2:18][CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14]3)=[N:10][CH:9]=2)=[CH:4][CH:3]=1.[F:26][C:27]([F:32])([F:31])[C:28]([O-:30])=[O:29]>>[OH:30][C:28]([C:27]([F:32])([F:31])[F:26])=[O:29].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH:13]3[CH2:18][CH2:17][CH2:16][NH:15][CH2:14]3)=[N:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 84468TrifluoroacetateHCID 69935244Tert-butyl 3-(5-(4-fluorophenyl)oxazol-2-yl)piperidine-1-carboxylate

Product 1

HCID 866735365-(4-Fluorophenyl)-2-(piperidin-3-yl)oxazole TFA Salt

Procedure

This compound was synthesized from tert-butyl 3-(5-(4-fluorophenyl)oxazol-2-yl)piperidine-1-carboxylate as described for example 46 step 4 (150 mg, crude) as a trifluoroacetate salt and it was carried through without further purification. MS (ESI) m/z: Calculated for C14H16FN2O: 246.12. found: 247.0 (M+H)+

Workup

  1. customwas carried through without further purification

Sources & evidence

ORD record
ord-b697462415b94b6082789b265a497d04
Source dataset
uspto-grants-2015_03
Patent number
US08981084B2

Reaction notes

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