Trifluoroacetate → 4-Phenyl-2-(piperazin-1-yl)pyrimidine TFA Salt

HRID 875006Notes

Reaction equation

HRID 875006 reaction equation
[C:1]1([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([N:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:26][C:27]([F:32])([F:31])[C:28]([O-:30])=[O:29]>>[OH:30][C:28]([C:27]([F:32])([F:31])[F:26])=[O:29].[C:1]1([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 84468TrifluoroacetateHCID 68577436Tert-butyl 4-(4-phenylpyrimidin-2-yl)piperazine-1-carboxylate

Product 1

HCID 866735384-Phenyl-2-(piperazin-1-yl)pyrimidine TFA Salt

Procedure

This compound was synthesized from tert-butyl 4-(4-phenylpyrimidin-2-yl)piperazine-1-carboxylate as described for example 46 step 4 (400 mg, crude) as a trifluoroacetate salt and it was carried through without further purification. MS (ESI) m/z: Calculated for C14H16N4: 240.14. found: 241.0 (M+H)+

Workup

  1. customwas carried through without further purification

Sources & evidence

ORD record
ord-56d8047ab4b14301a56c14c124696faa
Source dataset
uspto-grants-2015_03
Patent number
US08981084B2

Reaction notes

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