1-(2-Fluorophenyl)piperazine → HCID 53327905, compound

HRID 875009Notes

Reaction equation

HRID 875009 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.[F:14][C:15]([F:31])([F:30])[C:16]1[O:20][N:19]=[C:18]([C:21]2[CH:22]=[C:23]([CH:27]=[CH:28][CH:29]=2)[C:24](O)=[O:25])[N:17]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][N:11]([C:24]([C:23]2[CH:27]=[CH:28][CH:29]=[C:21]([C:18]3[N:17]=[C:16]([C:15]([F:30])([F:14])[F:31])[O:20][N:19]=3)[CH:22]=2)=[O:25])[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 705291-(2-Fluorophenyl)piperazineHCID 251808543-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid

Product 1

HCID 53327905HCID 53327905, compoundYield 28%

Procedure

This compound was synthesized from 1-(2-fluorophenyl)piperazine and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described for example 37 step 3 (45 mg, yield 28%). 1H NMR (400 MHz, CDCl3) δ 8.21-8.20 (m, 2H), 7.68-7.60 (m, 2H), 7.11-6.94 (m, 4H), 4.01 (m, 2H), 3.63 (m, 2H), 3.20-3.06 (m, 4H). MS (ESI) m/z: Calculated for C20H16F4N4O2: 420.12. found: 421.2 (M+H)+

Sources & evidence

ORD record
ord-dc07f1d0bf1540b486a029724418548e
Source dataset
uspto-grants-2015_03
Patent number
US08981084B2

Reaction notes

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