1-(2-Methoxyphenyl)piperazine → HCID 53327906, compound

HRID 875010Notes

Reaction equation

HRID 875010 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.[F:15][C:16]([F:32])([F:31])[C:17]1[O:21][N:20]=[C:19]([C:22]2[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=2)[C:25](O)=[O:26])[N:18]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([C:25]([C:24]2[CH:28]=[CH:29][CH:30]=[C:22]([C:19]3[N:18]=[C:17]([C:16]([F:31])([F:15])[F:32])[O:21][N:20]=3)[CH:23]=2)=[O:26])[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 251808543-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid

Product 1

HCID 53327906HCID 53327906, compoundYield 28%

Procedure

This compound was synthesized from 1-(2-methoxy-phenyl)-piperazine and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described for example 37 step 3 (63 mg, yield 28%). 1H NMR (400 MHz, CDCl3) δ 8.22-8.19 (m, 2H), 7.69-7.60 (m, 2H), 7.08-7.04 (m, 1H), 6.96-6.89 (m, 3H), 4.02 (m, 2H), 3.89 (s, 3H), 3.64 (m, 2H), 3.18 (m, 2H), 3.04 (m, 2H). MS (ESI) m/z: Calculated for C21H19F3N4O3: 432.14. found: 433.2 (M+H)+

Sources & evidence

ORD record
ord-7b4fca0d14934c56a06220902fb55a39
Source dataset
uspto-grants-2015_03
Patent number
US08981084B2

Reaction notes

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