tert-Butyl piperazine-1-carboxylate → tert-Butyl 4-((2-(4-fluorophenyl)oxazol-4-yl)methyl)piperazine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	tert-Butyl piperazine-1-carboxylate	HCID 143452	—
Reactant	2-(4-Fluoro-phenyl)-oxazole-4-carbaldehyde	HCID 21806235	—
Product	tert-Butyl 4-((2-(4-fluorophenyl)oxazol-4-yl)methyl)piperazine-1-carboxylate	HCID 69935494	42%

Reaction Steps

This compound was synthesized from tert-butyl piperazine-1-carboxylate and 2-(4-fluorophenyl)oxazole-4-carbaldehyde as described for example 82 step 3 (240 mg, yield 42%). 1H NMR (400 MHz, CDCl3) δ 8.07-8.03 (dd, J=9.1 Hz, 5.3 Hz, 2H), 7.59 (s, 1H), 7.16-7.12 (t, J=8.8 Hz, 2H), 3.54 (s, 2H), 3.49-3.47 (m, 4H), 2.52-2.49 (m, 4H), 1.46 (s, 9H). MS (ESI) m/z: Calculated for C19H24FN3O3: 361.18. found: 362.2 (M+H)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08981084B2
Source dataset	uspto-grants-2015_03
ORD ID	ord-513a38003de946b99d0626aae3fa12c6
Source note	uspto-grants-2015_03