2-Phenyl-4-carboxythiazole → HCID 46684680, compound

HRID 875034Notes

Reaction equation

HRID 875034 reaction equation
[N:1]1([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:14]1([C:20]2[S:21][CH:22]=[C:23]([C:25](O)=[O:26])[N:24]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[C:14]1([C:20]2[S:21][CH:22]=[C:23]([C:25]([N:4]3[CH2:5][CH2:6][N:1]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:2][CH2:3]3)=[O:26])[N:24]=2)[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 1389282-Phenyl-4-carboxythiazoleHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 46684680HCID 46684680, compoundYield 90%

Procedure

This compound was synthesized from tert-butyl piperazine-1-carboxylate and 2-phenylthiazole-4-carboxylic acid as described for example 37 step 3 (500 mg, yield 90%). 1H NMR (400 MHz, DMSO-d6) δ 8.20 (s, 1H), 8.00-7.96 (m, 2H), 7.56-7.53 (m, 3H), 3.76-3.64 (m, 4H), 3.43 (m, 4H), 1.42 (s, 9H). MS (ESI) m/z: Calculated for C19H23N3O3S: 373.15. found: 374.2 (M+H)+

Sources & evidence

ORD record
ord-08b4a6b26ee54a20b83c67707d724884
Source dataset
uspto-grants-2015_03
Patent number
US08981084B2

Reaction notes

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