HCID 42599313, compound → HCID 42599562, compound

HRID 875266Notes

Reaction equation

HRID 875266 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH:15]2[C:19](=[O:20])[O:18][C@H:17]3[C:21]4[C@@:26]([CH3:29])([CH2:27][CH2:28][C:16]23[OH:31])[CH2:25][CH2:24][CH2:23][C:22]=4[CH3:30])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[OH-].[OH-].[Pd+2]>[OH:31][C:16]12[CH2:28][CH2:27][C@:26]3([CH3:29])[CH:21]([CH:22]([CH3:30])[CH2:23][CH2:24][CH2:25]3)[C@@H:17]1[O:18][C:19](=[O:20])[CH:15]2[CH2:14][N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 2

HCID 42599313HCID 42599313, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 42599562HCID 42599562, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

Compound of example 27 (100 mg, 0.47 mmol) was dissolved in methanol (10 mL) and 10% Pd(OH)2/C was added to it. The reaction mixture was hydrogenated (hydrogen pressure, 1 atm) for 30 hours. The reaction mixture was filtered over celite and concentrated to obtain the title compound

Workup

  1. customfor 30 hours
  2. filtrationThe reaction mixture was filtered over celite and
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-130e284e544448098911b45ac776e3e3
Source dataset
uspto-grants-2015_03
Patent number
US08981131B2

Reaction notes

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