反应详情

温度

82.5 °C

Tapentadol (2 g) was dissolved in acetonitrile (15 ml), followed by addition of salicylic acid (1.25 g) to the solution at 25-30° C. and heating the reaction mass at 80-85° C. The resulting solution was slowly cooled to 20-25° C. and stirred for 2 hours at 20-25° C. The resulting solid was collected by filtration, washed with acetonitrile (10 ml) and dried at 40-45° C. under vacuum to give 2.5 g of tapentadol salicylate salt (Purity by HPLC: 99.75%).

1. temperatureThe resulting solution was slowly cooled to 20-25° C.
2. filtrationThe resulting solid was collected by filtration
3. washwashed with acetonitrile (10 ml)
4. customdried at 40-45° C. under vacuum