HRID875363

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

结构：C[C@H]1CO[C@@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N12.[Na]

HCID66594573

未命名化合物

HCID86688409

未命名化合物

PRODUCTS

生成物

结构：COC(=O)COC(=O)OCOc1c2n(cc(C(=O)NCc3ccc(F)cc3F)c1=O)C[C@H]1OC[C@H](C)N1C2=O

HCID44626085

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

结构：CCCC[N+](CCCC)(CCCC)CCCC.O=S(=O)([O-])O

催化剂HCID94433

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from methyl ({[(iodomethyl)oxy]carbonyl}oxy)acetate (103 mg, 0.374 mmol), 1b (80 mg, 0.187 mmol), potassium carbonate (78 mg, 0.5621 mmol), and tetrabutylammonium hydrogen sulfate (64 mg, 0.187 mmol), using a similar process to that described in example 1. 1H NMR (CDCl3) δ 10.20 (m, 1H), 8.39 (s, 1H), 7.33 (m, 1H), 6.78 (m, 2H), 6.00 (d, J=6.8 Hz, 1H), 5.88 (d, J=6.8 Hz, 1H), 5.30 (dd, J=10, 4 Hz, 1H), 4.63-4.58 (m, 4H), 4.43-4.28 (m, 4H), 3.93 (m, 1H), 3.73 (s, 2H), 3.66 (m, 1H), 1.38 (d, J=6 Hz, 3H). ES+ MS: 552 (M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fe6d58c4bda1474793fc92f82022e89f
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08981129B2
来源说明: uspto-grants-2015_03

反应 SMILES

I[CH2:2][O:3][C:4]([O:6][CH2:7][C:8]([O:10][CH3:11])=[O:9])=[O:5].[Na].[F:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[CH2:21][NH:22][C:23]([C:25]1[C:26](=[O:41])[C:27]([OH:40])=[C:28]2[C:33](=[O:34])[N:32]3[C@@H:35]([CH3:38])[CH2:36][O:37][C@@H:31]3[CH2:30][N:29]2[CH:39]=1)=[O:24].C(=O)([O-])[O-].[K+].[K+]>S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC>[F:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[CH2:21][NH:22][C:23]([C:25]1[C:26](=[O:41])[C:27]([O:40][CH2:2][O:3][C:4]([O:6][CH2:7][C:8]([O:10][CH3:11])=[O:9])=[O:5])=[C:28]2[C:33](=[O:34])[N:32]3[C@@H:35]([CH3:38])[CH2:36][O:37][C@@H:31]3[CH2:30][N:29]2[CH:39]=1)=[O:24]