Hydrochloric Acid → HCID 178492729, compound

HRID 875369Notes

Reaction equation

HRID 875369 reaction equation
[ClH:1].[CH2:2]([C:11]1[CH:45]=[CH:44][C:14]([C:15]([NH:17][C:18]2[CH:19]=[C:20]([NH:25]/[C:26](/[NH:29][C:30](=[O:43])[C:31]3[CH:36]=[C:35]([O:37][CH3:38])[C:34]([O:39][CH3:40])=[C:33]([O:41][CH3:42])[CH:32]=3)=[N:27]\[H])[CH:21]=[CH:22][C:23]=2[CH3:24])=[O:16])=[CH:13][CH:12]=1)C=CC1C=CC=CC=1.Cl>CC(O)=O>[ClH:1].[CH2:2]([C:11]1[CH:12]=[CH:13][C:14]([C:15]([NH:17][C:18]2[CH:19]=[C:20]([NH:25][C:26]([NH:29][C:30](=[O:43])[C:31]3[CH:36]=[C:35]([O:37][CH3:38])[C:34]([O:39][CH3:40])=[C:33]([O:41][CH3:42])[CH:32]=3)=[NH:27])[CH:21]=[CH:22][C:23]=2[CH3:24])=[O:16])=[CH:44][CH:45]=1)[C:11]1[CH:45]=[CH:44][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178478972HCID 178478972, compound

Product 1

HCID 178492729HCID 178492729, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of the compound Boc (7e) (103 mg, 0.15 mmol) in a mixture of AcOH (1.5 mL) and concentrated HCl (0.75 mL) is stirred at room temperature for 4 hours. The solvent is then evaporated and the residue is taken up in Et2O. The title compound is recovered in the form of white solid (7 g) (85 mg, 90%, Mp 112° C.).

Workup

  1. customThe solvent is then evaporated
  2. customThe title compound is recovered in the form of white solid (7 g) (85 mg, 90%, Mp 112° C.)

Sources & evidence

ORD record
ord-6026e159e8ba4983b7b58e97b97188ff
Source dataset
uspto-grants-2015_03
Patent number
US08981149B2

Reaction notes

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