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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 876138Generated: October 31, 2026

4,6-Dichloropyrimidine → HCID 60727007, compound

https://huagongshe.com/reaction/876138

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4,6-DichloropyrimidineHCID 70943—
ReactantBenzenamine, 4-(4-morpholinyl)-HCID 75655—
SolventIsopropanolHCID 3776—
ProductHCID 60727007HCID 6072700746%

Reaction Conditions

Temperature84 °C

Reaction Steps

100 mg of 4,6-dichloropyrimidine and 92 mg of p-morpholino aniline were dissolved in 5 mL of i-PrOH. The mixture obtained was refluxed at 84° C. for 6 hours under a nitrogen atmosphere. A colorless precipitate was formed which was collected by filtration. 6-Chloro-N-(4-morpholinophenyl)pyrimidin-4-amine was obtained in the form of a colorless solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08986994B2
Source datasetuspto-grants-2015_03
ORD IDord-a5d61a2c8e29460fb15674dfc974232b
Source noteuspto-grants-2015_03