4,6-Dichloropyrimidine → HCID 60727007, compound

HRID 876138Notes

Reaction equation

HRID 876138 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[O:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=2)[CH2:11][CH2:10]1>CC(O)C>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:19][C:18]2[CH:17]=[CH:16][C:15]([N:12]3[CH2:13][CH2:14][O:9][CH2:10][CH2:11]3)=[CH:21][CH:20]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 709434,6-DichloropyrimidineHCID 75655Benzenamine, 4-(4-morpholinyl)-

Product 1

HCID 60727007HCID 60727007, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
84 °C

Procedure

100 mg of 4,6-dichloropyrimidine and 92 mg of p-morpholino aniline were dissolved in 5 mL of i-PrOH. The mixture obtained was refluxed at 84° C. for 6 hours under a nitrogen atmosphere. A colorless precipitate was formed which was collected by filtration. 6-Chloro-N-(4-morpholinophenyl)pyrimidin-4-amine was obtained in the form of a colorless solid.

Workup

  1. customThe mixture obtained
  2. customA colorless precipitate was formed which
  3. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-a5d61a2c8e29460fb15674dfc974232b
Source dataset
uspto-grants-2015_03
Patent number
US08986994B2

Reaction notes

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