3-Amino-1-propanol → HCID 53259295, compound

HRID 876183Notes

Reaction equation

HRID 876183 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.[CH2:17]([CH2:20][OH:21])[CH2:18][NH2:19]>>[CH3:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([NH:8][C:6]2[N:7]=[C:2]([NH:19][CH2:18][CH2:17][CH2:20][OH:21])[CH:3]=[CH:4][CH:5]=2)=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 53410281HCID 53410281, compound

Product 1

HCID 53259295HCID 53259295, compoundYield 64%

Procedure

95 mg of 6-chloro-N-(4-methoxyphenyl)pyridin-2-amine were mixed with 244 mg of n-propanolamine and the mixture obtained was treated in a vial analogously to the method as set out in Example 16b. 3-(6-(4-Methoxyphenylamino)pyridin-2-ylamino)propan-1-ol was obtained in the form of a brown oil.

Workup

  1. customthe mixture obtained
  2. additionwas treated in a vial analogously to the method

Sources & evidence

ORD record
ord-d700e9eb1bea44aa8589f8b562b9320e
Source dataset
uspto-grants-2015_03
Patent number
US08986994B2

Reaction notes

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