3-Amino-1-propanol → HCID 53261254, compound

HRID 876186Notes

Reaction equation

HRID 876186 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:11][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.[CH2:22]([CH2:25][OH:26])[CH2:23][NH2:24]>>[O:15]([C:12]1[CH:13]=[CH:14][C:9]([NH:8][C:6]2[N:7]=[C:2]([NH:24][CH2:23][CH2:22][CH2:25][OH:26])[CH:3]=[CH:4][CH:5]=2)=[CH:10][CH:11]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 63587641HCID 63587641, compound

Product 1

HCID 53261254HCID 53261254, compoundYield 73%

Procedure

A mixture of 150 mg of 6-chloro-N-(4-phenoxyphenyl)pyridin-2-amine in 304 mg of n-propanolamine in a screw cap vial under argon was treated analogously to the method as set out in Example 16b. 3-(6-(4-Phenoxyphenylamino)pyridin-2-ylamino)propan-1-ol was obtained in the form of a brown oil.

Workup

  1. customcap vial under argon
  2. additionwas treated analogously to the method

Sources & evidence

ORD record
ord-acbdaeb1395047e09800f3d9141ea4be
Source dataset
uspto-grants-2015_03
Patent number
US08986994B2

Reaction notes

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