HCID 66701425, compound → HCID 66701320, compound

HRID 876231Notes

Reaction equation

HRID 876231 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][CH:12]=[C:13]([O:15][CH3:16])[CH:14]=2)=[CH:5][CH:4]=1)[CH3:2]>C(O)(=O)C>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[CH2:14][CH:13]([O:15][CH3:16])[CH2:12][NH:11][CH2:10]2)=[CH:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 1

HCID 66701425HCID 66701425, compound

Product 1

HCID 66701320HCID 66701320, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 1.0 g (4.7 mmol) of 3-(4-ethylphenyl)-5-methoxypyridine in 120 ml of acetic acid was reacted according to General Method 5A. The solution was concentrated under reduced pressure. The crude product was purified by flash chromatography (silica gel, dichloromethane/methanol gradient). Yield: 880 mg (86% of theory)

Workup

  1. concentrationThe solution was concentrated under reduced pressure
  2. customThe crude product was purified by flash chromatography (silica gel, dichloromethane/methanol gradient)

Sources & evidence

ORD record
ord-64950271b4e84d9f99ebabaea811eaa9
Source dataset
uspto-grants-2015_03
Patent number
US08987248B2

Reaction notes

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