HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-{5-[3-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide → N-{5-[3-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-{5-[3-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide | HCID 66701292 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-{5-[3-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide | HCID 66701267 | — |
Reaction Steps
A solution of 840 mg (1.82 mmol) of N-{5-[3-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide in 100 ml of glacial acetic acid was reacted according to General Method 6A. The solution was concentrated under reduced pressure. The product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 700 mg
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987248B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-31b0e3a16f834997a2d8c9fbf8810897 |
| Source note | uspto-grants-2015_03 |