HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-{5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide → N-{5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-{5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide | HCID 66701368 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-{5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide | HCID 66701397 | — |
Reaction Steps
A solution of 1.0 g (2.9 mmol) of N-{5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide in 120 ml of glacial acetic acid was reacted according to General Method 6A. The solution was concentrated under reduced pressure. The product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 657 mg (50% pure).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987248B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-2e9c2f26daaf444dabbf4bcb30935231 |
| Source note | uspto-grants-2015_03 |