Potassium tert-butoxide → 1-(1,4-Dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid

HRID 876255Notes

Reaction equation

HRID 876255 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][N:8]([C:11]([N:13]3[CH2:18][CH:17]([C:19]4[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=4)[CH2:16][CH:15]([C:29]([O:31]C)=[O:30])[CH2:14]3)=[O:12])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.CC(C)([O-])C.[K+]>>[O:4]1[C:5]2([CH2:10][CH2:9][N:8]([C:11]([N:13]3[CH2:18][CH:17]([C:19]4[CH:24]=[CH:23][C:22]([C:25]([F:27])([F:26])[F:28])=[CH:21][CH:20]=4)[CH2:16][CH:15]([C:29]([OH:31])=[O:30])[CH2:14]3)=[O:12])[CH2:7][CH2:6]2)[O:1][CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 66701334Methyl 1-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylate

Product 1

HCID 667617021-(1,4-Dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid

Procedure

5.15 g (11.3 mmol) of the compound from Example 59A and 12.7 g (113 mmol) of potassium tert-butoxide were reacted according to the General Method 7A. Yield: 5.00 g (99% of theory)

Sources & evidence

ORD record
ord-b2aea14e607f49f28f7a61c90abfd437
Source dataset
uspto-grants-2015_03
Patent number
US08987248B2

Reaction notes

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