HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium tert-butoxide → 1-(1,4-Dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | Methyl 1-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylate | HCID 66701334 | — |
| Product | 1-(1,4-Dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid | HCID 66761702 | — |
Reaction Steps
5.15 g (11.3 mmol) of the compound from Example 59A and 12.7 g (113 mmol) of potassium tert-butoxide were reacted according to the General Method 7A. Yield: 5.00 g (99% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987248B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-b2aea14e607f49f28f7a61c90abfd437 |
| Source note | uspto-grants-2015_03 |