Aniline → 5-(4-Ethylphenyl)-N-phenyl-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-carboxamide
Reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:21][CH2:20][CH2:19][CH2:18]3)=[O:16])[CH2:12][CH:11]([C:22](O)=[O:23])[CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].[NH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH2:4]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:18][CH2:19][CH2:20][CH2:21]3)=[O:16])[CH2:12][CH:11]([C:22]([NH:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[O:23])[CH2:10]2)=[CH:2][CH:1]=1)[CH3:5]Participants
3
Procedure
33 mg (0.10 mmol) of 5-(4-ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-carboxylic acid (Example 11A) and 10 mg (0.11 mmol, 1.1 eq.) of aniline were reacted according to General Method 1. Yield: 26 mg (64% of theory)
Sources & evidence
- ORD record
- ord-3962b0f5f3504fa9b51000bd7326d84f
- Source dataset
- uspto-grants-2015_03
- Patent number
- US08987248B2
Reaction notes
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