Isocyanatocyclopropane → HCID 66761748, compound

HRID 876303Notes

Reaction equation

HRID 876303 reaction equation
FC(F)(F)C(O)=O.[CH:8]1([C:13]([N:15]2[CH2:20][CH:19]([C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH3:28])=[CH:23][CH:22]=3)[CH2:18][CH:17]([NH2:29])[CH2:16]2)=[O:14])[CH2:12][CH2:11][CH2:10][CH2:9]1.[CH:30]1([N:33]=[C:34]=[O:35])[CH2:32][CH2:31]1>>[CH:8]1([C:13]([N:15]2[CH2:20][CH:19]([C:21]3[CH:22]=[CH:23][C:24]([CH2:27][CH3:28])=[CH:25][CH:26]=3)[CH2:18][CH:17]([NH:29][C:34]([NH:33][CH:30]3[CH2:32][CH2:31]3)=[O:35])[CH2:16]2)=[O:14])[CH2:9][CH2:10][CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 637659IsocyanatocyclopropaneHCID 667013441-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate

Product 1

HCID 66761748HCID 66761748, compound

Procedure

108 mg (0.22 mmol) of 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate (Example 7A) and 22 mg (0.26 mmol, 1.2 eq.) of cyclopropyl isocyanate were reacted according to General Method 4. Yield: 64 mg (76% of theory)

Sources & evidence

ORD record
ord-9c1e5209869f4ab1ba71687603eedf59
Source dataset
uspto-grants-2015_03
Patent number
US08987248B2

Reaction notes

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