反应详情

55 mg (0.14 mmol) of tert-butyl [1-({3-(3,4-dimethylphenyl)-5-[(phenylcarbonyl)amino]piperidin-1-yl}carbonyl)cyclobutyl]carbamate were dissolved in 7 ml of dioxane, 1.5 ml of concentrated hydrochloric acid were added and the mixture was immediately concentrated on a rotary evaporator. The residue was then purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 19 mg (39% of theory)

1. concentrationthe mixture was immediately concentrated on a rotary evaporator
2. customThe residue was then purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient)