反应详情

33 mg (0.06 mmol) of tert-butyl [4-({3-(3,4-dimethylphenyl)-5-[(phenylcarbonyl)amino]piperidin-1-yl}carbonyl)tetrahydro-2H-pyran-4-yl]carbamate were dissolved in 4 ml of dioxane, 1 ml of concentrated hydrochloric acid was added and the mixture was immediately concentrated on a rotary evaporator. The residue was then purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 15 mg (57% of theory)

1. concentrationthe mixture was immediately concentrated on a rotary evaporator
2. customThe residue was then purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient)