Hydrochloric Acid → HCID 67235268, compound

HRID 876422Notes

Reaction equation

HRID 876422 reaction equation
[N:1]1[N:2]=[C:3]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[C:13]([O:20][CH:21]4[CH2:27][CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22]4)[CH:14]=[CH:15][CH:16]=3)[N:11]=2)[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.[ClH:35]>C(Cl)(Cl)Cl>[ClH:35].[ClH:35].[N:1]1[N:2]=[C:3]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[C:13]([O:20][CH:21]4[CH2:27][CH2:26][CH2:25][NH:24][CH2:23][CH2:22]4)[CH:14]=[CH:15][CH:16]=3)[N:11]=2)[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67234455HCID 67234455, compound

Product 1

HCID 67235268HCID 67235268, compoundYield 78.7%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of the product from Step B (0.40 g, 0.870 mmol) in CHCl3 (9 mL) was added hydrogen chloride (7.62 mL, 30.5 mmol, 4.0 M in dioxane) and the reaction was stirred at ambient temperature for 5 hours. The resulting yellow solid was removed by direct filtration and the solid was washed with Et2O and dried in vacuo to provide 0.296 g (72%) of the desired product as a yellow solid. MS ESI (+) m/z 360.1 (M+1) detected.

Workup

  1. customThe resulting yellow solid was removed by direct filtration
  2. washthe solid was washed with Et2O
  3. customdried in vacuo

Sources & evidence

ORD record
ord-297ec18274a949149677494caa276d77
Source dataset
uspto-grants-2015_03
Patent number
US08987251B2

Reaction notes

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